A collection of disease information resources and questions answered by our Genetic and Rare Diseases Information Specialists for Hyperkeratosis lenticularis . Flegel disease is also known as ‘hyperkeratosis lenticularis perstans’. It was first described by Flegel in It is characterised by red-brown papules with. Hyperkeratosis lenticularis perstans (HLP) is a rare cutaneous disorder occurring in older persons and manifested by multiple benign pink to reddish-brown.
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Hyperkeratosis Lenticularis Perstans (Flegel’s disease)
Clinical input is often very helpful in making a diagnosis histopathologically. Hyperkeratosis lenticularis perstans HLP Flegel disease.
It was first described by Flegel in No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The disorder is thought to be caused by alterations in the membrane-coating granules lamellar granulesOdland bodies of the keratinocytes.
While there are reports of improvements with corticosteroids, vitamin D analogs and 5-fluorouracil, there have also been reports of failure to respond to treatment with the first two of these.
Stucco keratoses do not bleed when the scale is peeled back, and will show papillomatosis on pathology. Flegel’s disease, also known as hyperkeratosis lenticularis perstans, is a rare skin disease characterized by small reddish-brown asymptomatic hyperkeratotic papules usually located on the lower extremities. Histopathological differences between early and old lesions of hyperkeratosis Lenticularis Perstans Flegel’s disease.
Degenerative diseases and perforating disorders. Lamellar bodies in hyperkeratosis lenticularis perstans. The lamellar granules release lipids that are essential to the process of desquamation; without normal desquamation, hyperkeratosis characteristic of this disease develops.
It may also be hereditary, with autosomal dominant transmission. Lesions are not usually painful. Treatment of lesions include:.
OMIM Entry – % – HYPERKERATOSIS LENTICULARIS PERSTANS; HLP
Treatment Options Treatment options are summarized in Table I. Finally, short-term psoralen with ultraviolet radiation has been used in a normal psoriasis regimen. Actinic keratosis — Actinic dysplasia is seen. Who is at Risk for Developing this Disease?
The histopathological features are hyperorthokeratosis, epidermal atrophy and band-like inflammatory infiltrate in the superficial dermis. Case report of a rare entity.
None are generally needed. Kyrle disease — This condition is clinically similar and may share some pathogenic components.
Cooper, S, George, S. Indian J Dermatol ; Dermatopathology glossary Flegel disease Dermatopathology lehticularis Books about skin diseases: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine.
Ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil. How to cite this article: Similar lesions on forearms Click here to view. Few lesions of similar morphology on trunk Click perstns to view. Disseminated superficial actinic porokeratosis primarily involves the lower legs and sun exposed areas, as well as having the pathognomonic coronoid lamella histologicially.
The cause of the disease is unknown. Systemic retinoids have been reported, but justifying their letnicularis side effects to treat a benign asymptomatic condition is difficult. There was no recurrence of lesions in the biopsied areas after two years of follow-up.
J Am Acad of Dermatol. Expert curators review the literature and organize it to facilitate elnticularis work. The disorder hyperkeratoeis first described by Flegel summary by Bean, However, according to some authors, it may be the result of a keratinization disorder and may be triggered by hyperkerayosis radiation. How to cite this URL: Lesions on thighs Click here to view. If you have any concerns with your skin or its treatment, see a dermatologist for advice.
Hyperkeratosis lenticularis perstans: Case report of a rare entity Patel KB – Indian J Dermatol
Approved by the Advisory Board and accepted for publication on Hyperkeratosis lenticularis perstans Flegel’s disease – successful treatment with topical corticosteroids. Diagnosis is confirmed by histological examination and the clinical evolution of the disease. The etiology of hyperkeratosis lenticularis perstans is unknown.
The lesions of hyperkeratosis lenticularis perstans are usually asymptomatic but cosmetically frustrating. The authors suggested that there may be pperstans inherited tendency to epithelial neoplasia in this family.
Flegel disease has been reported to rarely affect some families that were also prone to skin and gastrointestinal cancers.
Such treatments include CO2 laser, curettage and electrocoagulation. Histopathological differences between early and old leticularis of hyperkeratosis lenticularis perstans Flegel’s Disease. There are no systemic manifestions of hyperkeratosis lenticularis perstans.